Scientific abstract

Background

Experimental, clinical, and epidemiologic evidence suggests that 25-hydroxyvitamin D [25(OH)D], the best biomarker of vitamin D status, may protect against the development of different types of cancer as well as of their progression. However, there is limited data on the association between 25(OH)D and risk and prognosis of bladder cancer. Furthermore, the mechanisms through which it may impact on bladder carcinogenesis are not fully understood.

Objectives

We aimed at:

1. Evaluating the association between concentrations of 25(OH)D in plasma and risk of bladder cancer overall and for sub-phenotypes
2. Analyzing 25(OH)D*candidate-SNPs interactions
3. Assessing the independent prognostic role of 25(OH)D in bladder cancer
4. Performing a genome wide association study (GWAS) with 25(OH)D levels.

Methods

The study considered 1,125 cases of bladder cancer and 1,028 hospital controls with available plasma samples recruited in the Spanish Bladder Cancer/EPICURO…