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PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity

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PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity

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Sci. Signal.  18 Jul 2017:
Vol. 10, Issue 488, eaaf2969
DOI: 10.1126/scisignal.aaf2969

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 Dual modulator of macrophages

The kinase PI3Kγ is thought to inhibit classical macrophage activation, an effect that enables tumor progression. However, Breasson et al. found that PI3Kγ promoted the activation of macrophages in two different mouse models of obesity.
Analysis of mice with whole-body or tissue-specific deficiencies in PI3Kγ revealed…

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Connie Dello Buono is based in San Jose California. Her first ebook is about women's health, Birthing Ways Healing Ways and her recent one is about cancer prevention, Curated Healing Ways. She had helped women have holistic childbirth as childbirth educator, founded Motherhealth, to serve seniors in the bay area with holistic caregivers and blogs at www.clubalthea.com with more than 10,000 health and finance related posts. She is California Life Insurance licensed providing life insurance for older adults with health issues and helping women retire safely with income for life. lifeinsurance4women.com aims to serve all women in the USA , protect their mortgage, life, funeral and burial expenses, retirement income, and whole and term life insurance policies with long term care and disability benefits, cash back or return of premiums. 3 Benefit plans - Mortgage protection using term life insurance to pay for mortgage balance in event of death - Final Expense plan using Single Issue Whole Life Insurance, with cash back, disability benefit and guaranteed in the presence of health issues - Fixed Index Annuity retirement plan for safe, accessibility, less fees, less taxes, avoids probate as it goes directly to beneficiaries, rate of return with no downside market participation. She brings compassion and understanding to the needs of her clients, bringing holistic approach in health and life insurance. Her goal is to free families from worries especially during covid with caregivers and life insurance in the presence of health issues, especially for women. She can be reached at 408-854-1883 , motherhealth@gmail.com or connie@connielifeins.com

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