How can the replacement rates of the cells in various tissues in our body be measured? For rapidly renewing tissues common labeling tricks can be useful as with the nucleotide analog BrdU. But what about the very slow tissues that take years or a lifetime? In a fascinating example of scientific serendipity, Cold War nuclear tests have come to the aid of scientists as a result of the fact that they changed the atmospheric concentrations of the isotope carbon-14 around the globe. These experiments are effectively pulse-chase experiments but at the global scale. Carbon-14 has a half-life of 5730 years, and thus even though radioactive, the fraction that decays within the lifetime of an individual is negligible and this timescale should not worry us. The “labeled” carbon in the atmosphere is turned into CO₂ and later into our food through carbon fixation by plants. In our bodies, this carbon…