Healthcare providers and insurers in the U.S. may be efficient and effective in their individual roles, but the system as a whole, hamstrung by regulation and dysfunctional fee-for-service economics, is not.

By most estimates, about 40 percent of the $3 trillion the U.S. spends on healthcare each year could have been avoided.

That represents an enormous pot of potential profits for companies that successfully disrupt the system.

The U.S. may not deserve to be ranked dead last in healthcare compared to our peer nations, as it was in a recent report from Commonwealth Fund. But considering that most of those peers spend less than half what we do, there are clearly issues of value.

And in a time of rising consumer expectations, the user experience of healthcare is falling behind. Particularly when compared to Uber for personal transport, Amazon for shopping, or Open Table for picking a restaurant and making…