There is an increase in mortality (2001-2010) associated with PH among men, women, and all race and ethnic groups, and from several conditions commonly associated with PH (hypertension and coronary heart disease, aortic stenosis, liver disease and cirrhosis, and autoimmune disease) but also from renal disease and diabetes, while finding that PH-associated mortality decreased over time from deaths due to congenital malformations among newborns, and for emphysema, chronic lower respiratory disease, and pulmonary embolism.

Approximately one-half of deaths associated with PH occur among those under 75 years of age. Although PH death rates have been stable for those aged 1 to 74 years over the past decade, the identified increases in PH death among those with a UCOD from hypertension, coronary heart disease, and valvular disease may be avoidable with improved public health efforts in the primary prevention of heart disease. The increased mortality from autoimmune conditions in association with…